Myaware share the growing concern regarding the continued disruption to the supply of Propantheline Bromide (Pro-Banthine). We have been consistently contacting the supplier Kyowa Kirin, and two manufacturers in Grunenthal and Haupt Pharma. Unfortunately, some companies have been unresponsive, while others have only confirmed they have no set date for resupply.

To try and mitigate this continued issue, we have been in contact with our medical committee, who have provided the following guidance:

-        If your primary side effect from pyridostigmine use is diarrhoea, you can use any medicine that works to combat this. Examples are; Imodium, Pepto-Bismol, Codeine phosphate, Lomotil (co-phenotrope), and Rifaximin. Most if not all of these medicines will be listed as contraindicated in myasthenia due to being muscle relaxants. With this in mind, please confirm with your GP or neurologist that they are happy for you to take this.

-        If you are experiencing stomach cramps, alternatives to Propantheline Bromide are: Buscopan, Mebeverine, and Oxybutynin. All three again need to be approved by your neurologist before initiating treatment.


In addition, the Community Pharmacy England website has listed the following importers as having a supply of unlicensed Propantheline:

-        Alium Medical

-        Mawdsley’s Unlicensed

-        Target Healthcare


These alternative suppliers should be contactable by pharmacies in Scotland, Northern Ireland, and Wales also.


If you are able, please request that your pharmacy or neurologist put in a special-order request for Propantheline 15mg tablets from one of these companies using an FP10 paper.

As of April 23rd 2024, we have been advised by Community Pharmacy England that there remains some generic supply but there has not been an update made by the companies involved. Myaware have also approached the Community Pharmacies in Scotland, Northern Ireland, and Wales for an update, and we will post these here when we hear back. We have also reached out to the Department of Health and Social Care and await comment.

Update (May 2nd) – Myaware have been contacted by the Department of Health and Social Care who have confirmed 15 mg Propantheline Bromide is back in stock. If you are experiencing a shortage, please let our Research and Partnerships Officer know ([email protected]).

Update (June 4th) – Myaware reported the continued shortage of propantheline bromide to the DHSC, who have since replied to say that the supplier (Genesis Pharmaceuticals) is delivering further stock to wholesalers (AAH Pharmaceuticals, Alliance Healthcare, and Phoenix Healthcare throughout the week and this should be with them shortly.

Visit the Community Pharmacy England  website discussing this shortage.

More information regarding this shortage.